منابع مشابه
Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage.
Matrix vesicles, associated with initial calcification in cartilage, have been isolated from bovine fetal epiphyseal cartilage. Cartilage was digested with collagenase, then partitioned into seven fractions by differential centrifugation. The cellular fractions contained over 80% of the DNA in the digest. The extracellular fraction that contained matrix vesicles, in which apatite crystals were ...
متن کاملComprehensive Gene Expression of Rat Epiphyseal Growing Cartilage
Introduction Skeletal growth in long bones depends on the proliferation and subsequent differentiation of chondrocytes in the growth plate. The cellular and molecular events that regulate the highly ordered progression of chondrocytes are under precise spatial and temporal genetic control. We have previously reported the initial characterization of the most abundant genes in this tissue (1). Th...
متن کاملCartilage Resorption in the Tibial Epiphyseal Plate of Growing Rats
An electron microscopic study of the tibial epiphyseal plates of growing rats reveals that the resorption of unmineralized and mineralized cartilage occurs by two different mechanisms. During resorption the unmineralized transverse cartilaginous walls between chondrocytes are invaded by capillary sprouts. At the resorption zone, numerous cytoplasmic processes derived primarily from the perivasc...
متن کاملHistology of epiphyseal cartilage calcification and endochondral ossification.
Cartilage calcification is carried out by chondrocytes as they hypertrophy and begin to secrete matrix vesicles. Calcification initiates when calcium phosphates appear inside these matrix vesicles, forming hydroxyapatite crystals that eventually break through the membrane to form calcifying globules, as in bone calcification. However, the extracellular environment in cartilage is different from...
متن کاملVesicles Associated with Calcification in the Matrix of Epiphyseal Cartilage
Vesicles have been identified within the cartilage matrix of the upper tibial epiphyseal plate of normal mice . They were seen at all levels within the plate and usually did not appear to be in contact with cartilage cells . Vesicles were concentrated within the matrix of the longitudinal septa from the proliferative zone downward . They varied considerably in size (-300 A to --I μ) and in shap...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1941
ISSN: 0003-4932
DOI: 10.1097/00000658-194112000-00014